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Secondary Metabolites with α-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus Talaromyces sp. CY-3
| Content Provider | MDPI |
|---|---|
| Author | Yang, Wencong Tan, Qi Yin, Yihao Chen, Yan Zhang, Yi Wu, Jianying Gao, Leyao Wang, Bo She, Zhigang |
| Copyright Year | 2021 |
| Description | Eight new compounds, including two sambutoxin derivatives (1–2), two highly oxygenated cyclopentenones (7–8), four highly oxygenated cyclohexenones (9–12), together with four known sambutoxin derivatives (3–6), were isolated from semimangrove endophytic fungus Talaromyces sp. CY-3, under the guidance of molecular networking. The structures of new isolates were elucidated by analysis of detailed spectroscopic data, ECD spectra, chemical hydrolysis,$ ^{13}$C NMR calculation, and DP4+ analysis. In bioassays, compounds 1–5 displayed better α-glucosidase inhibitory activity than the positive control 1-deoxynojirimycin $(IC_{50}$ = 80.8 ± 0.3 μM), and the $IC_{50}$ value was in the range of 12.6 ± 0.9 to 57.3 ± 1.3 μM. |
| Starting Page | 492 |
| e-ISSN | 16603397 |
| DOI | 10.3390/md19090492 |
| Journal | Marine drugs |
| Issue Number | 9 |
| Volume Number | 19 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-08-28 |
| Access Restriction | Open |
| Subject Keyword | Marine drugs Marine Drugs Infectious Diseases Talaromyces Sp. Molecular Networking Sambutoxin Polyketides Α-glucosidase |
| Content Type | Text |
| Resource Type | Article |
