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Synthetic Approach to Diversified Imidazo[2,1-b][1,3]thiazines and Its Evaluation as Non-Steroidal Anti-Inflammatory Agents †
| Content Provider | MDPI |
|---|---|
| Author | Slyvka, Nataliia Holota, Serhii Saliyeva, Lesya Vovk, Mykhailo |
| Copyright Year | 2021 |
| Description | The present work is devoted to the synthesis of imidazo[2,1-b][1,3]thiazine derivatives as possible anti-inflammatory agents. The synthetic approach to (2-pyridinyloxy) substituted imidazo[2,1-b][1,3]thiazines based on the interaction of the polysubstituted 2-chloropyridines with 3-hydroxy-imidazo[2,1-b][1,3]thiazines was proposed. Selective nucleophilic substitution in position 2 of a pyridine ring was observed in the mentioned reaction. The synthesized (2-pyridinyloxy) substituted imidazo[2,1-b][1,3]thiazines drug-like properties were studied in silico using SwissADME and anti-inflammatory activity in the carrageenan test in vivo. Hit-compounds with satisfactory drug-like and pharmacological features were identified as promising objects for forthcoming structure optimization and in-depth studies. |
| Starting Page | 82 |
| DOI | 10.3390/ecsoc-25-11692 |
| Issue Number | 1 |
| Volume Number | 8 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-11-14 |
| Access Restriction | Open |
| Subject Keyword | Imidazo[2,1-b][1,3]thiazine Pyridine Small Molecules Alkylation Drug-like Anti-inflammatory Activity Nsaids |
| Content Type | Text |
