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Efficacy and Safety of Carbon-Ion Radiotherapy for Stage I Non-Small Cell Lung Cancer with Coexisting Interstitial Lung Disease
| Content Provider | MDPI |
|---|---|
| Author | Okano, Naoko Kubo, Nobuteru Yamaguchi, Koichi Kouno, Shunichi Miyasaka, Yuhei Mizukami, Tatsuji Shirai, Katsuyuki Saitoh, Jun-Ichi Ebara, Takeshi Kawamura, Hidemasa Maeno, Toshitaka Ohno, Tatsuya |
| Copyright Year | 2021 |
| Description | Interstitial lung disease (ILD) is a risk factor both for the development and treatment failure of lung cancer. In this retrospective study, we analyzed the outcome of carbon-ion radiotherapy (CIRT) in 124 patients with clinical stage I non-small cell lung cancer (NSCLC), of whom 26 (21%) had radiological signs of pre-existing ILD. ILD was diagnosed retrospectively by a pulmonologist based on critical review of CT-scans. Ninety-eight patients were assigned to the non-ILD group and 26 patients (21.0%) to the ILD group. There were significant differences in pre-treatment KL-6 values between the two groups. The three year overall survival and cause-specific survival rates were 83.2% and 90.7%, respectively, in the non-ILD group, and 59.7% and 59.7%, respectively, in the ILD group (between-group differences, p = 0.002 and p < 0.001). Radiation pneumonitis worse than Grade 2 was observed in three patients (3.0%) in the non-ILD group and two patients (7.6%) in the ILD group (p = 0.29). There were no cases of acute exacerbation in the ILD group. CIRT for stage I NSCLC was as safe in the ILD group as in the non-ILD group. Coexisting ILD was a poor prognostic factor in CIRT for clinical stage I lung cancer. |
| Starting Page | 4204 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13164204 |
| Journal | Cancers |
| Issue Number | 16 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-08-20 |
| Access Restriction | Open |
| Subject Keyword | Cancers Radiology, Nuclear Medicine and Imaging Non-small Cell Lung Cancer Stage I Carbon-ion Radiotherapy Interstitial Lung Disease |
| Content Type | Text |
| Resource Type | Article |
