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Effects of Pitavastatin, Atorvastatin, and Rosuvastatin on the Risk of New-Onset Diabetes Mellitus: A Single-Center Cohort Study
| Content Provider | MDPI |
|---|---|
| Author | Liu, Wei-Ting Lin, Chin Tsai, Min-Chien Cheng, Cheng-Chung Chen, Sy-Jou Liou, Jun-Ting Lin, Wei-Shiang Cheng, Shu-Meng Lin, Chin-Sheng Tsao, Tien-Ping |
| Copyright Year | 2020 |
| Description | Statins constitute the mainstay treatment for atherosclerotic cardiovascular disease, which is associated with the risk of new-onset diabetes mellitus (NODM). However, the effects of individual statins on the risk of NODM remain unclear. We recruited 48,941 patients taking one of the three interested statins in a tertiary hospital between 2006 and 2018. Among them, 8337 non-diabetic patients taking moderate-intensity statins (2 mg/day pitavastatin, 10 mg/day atorvastatin, and 10 mg/day rosuvastatin) were included. The pitavastatin group had a higher probability of being NODM-free than the atorvastatin and rosuvastatin groups during the 4-year follow-up (log-rank test: p = 0.038). A subgroup analysis revealed that rosuvastatin had a significantly higher risk of NODM than pitavastatin among patients with coronary artery disease (CAD) (adjusted HR [aHR], 1.47, 95% confidence interval [CI], 1.05–2.05, p = 0.025), hypertension (aHR, 1.26, 95% CI, 1.00–1.59, p = 0.047), or chronic obstructive pulmonary disease (COPD) (aHR, 1.74, 95% CI, 1.02–2.94, p = 0.04). We concluded that compared with rosuvastatin, reduced diabetogenic effects of pitavastatin were observed among patients treated with moderate-intensity statin who had hypertension, COPD, or CAD. Additional studies are required to prove the effects of different statins on the risk of NODM. |
| Starting Page | 499 |
| e-ISSN | 22279059 |
| DOI | 10.3390/biomedicines8110499 |
| Journal | Biomedicines |
| Issue Number | 11 |
| Volume Number | 8 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-11-13 |
| Access Restriction | Open |
| Subject Keyword | Biomedicines Cardiology and Cardiovascular Diseases Statins New-onset Diabetes Mellitus Atherosclerotic Cardiovascular Disease |
| Content Type | Text |
| Resource Type | Article |
