NDLI: A Review of Completed and Ongoing Complement Inhibitor Trials for Geographic Atrophy Secondary to Age-Related Macular Degeneration

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A Review of Completed and Ongoing Complement Inhibitor Trials for Geographic Atrophy Secondary to Age-Related Macular Degeneration

Content Provider	MDPI
Author	Halawa, Omar Lin, Jonathan Miller, Joan Vavvas, Demetrios
Copyright Year	2021
Description	Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among older adults in the Western world. While therapies exist for patients with exudative AMD, there are currently no approved therapies for non-exudative AMD and its advanced form of geographic atrophy (GA). The discovery of genetic variants in complement protein loci with increased susceptibility to AMD has led to the investigation of the role of complement inhibition in AMD with a focus on GA. Here, we review completed and ongoing clinical trials evaluating the safety and efficacy of these studies. Overall, complement inhibition in GA has yielded mixed results. The inhibition of complement factor D has failed pivotal phase 3 trials. Studies of C3 and C5 inhibition meeting their primary endpoint are limited by high rates of discontinuation and withdrawal in the treatment arm and higher risks of conversion to exudative AMD. Studies evaluating other complement members (CFB, CFH, CFI and inhibitors of membrane attack complex—CD59) are ongoing and could offer other viable strategies.
Starting Page	2580
e-ISSN	20770383
DOI	10.3390/jcm10122580
Journal	Journal of clinical medicine
Issue Number	12
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-06-11
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Gerontology Complement Inhibitors Age-related Macular Degeneration Amd Exudation Exudative Amd Wet Amd Factor D
Content Type	Text
Resource Type	Article

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