NDLI: Reactive Species-Activatable AIEgens for Biomedical Applications

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Reactive Species-Activatable AIEgens for Biomedical Applications

Content Provider	MDPI
Author	Kang, Xiaoying Li, Yue Yin, Shuai Li, Wen Qi, Ji
Copyright Year	2022
Description	Precision medicine requires highly sensitive and specific diagnostic strategies with high spatiotemporal resolution. Accurate detection and monitoring of endogenously generated biomarkers at the very early disease stage is of extensive importance for precise diagnosis and treatment. Aggregation-induced emission luminogens (AIEgens) have emerged as a new type of excellent optical agents, which show great promise for numerous biomedical applications. In this review, we highlight the recent advances of AIE-based probes for detecting reactive species (including reactive oxygen species (ROS), reactive nitrogen species (RNS), reactive sulfur species (RSS), and reactive carbonyl species (RCS)) and related biomedical applications. The molecular design strategies for increasing the sensitivity, tuning the response wavelength, and realizing afterglow imaging are summarized, and theranostic applications in reactive species-related major diseases such as cancer, inflammation, and vascular diseases are reviewed. The challenges and outlooks for the reactive species-activatable AIE systems for disease diagnostics and therapeutics are also discussed. This review aims to offer guidance for designing AIE-based specifically activatable optical agents for biomedical applications, as well as providing a comprehensive understanding about the structure–property application relationships. We hope it will inspire more interesting researches about reactive species-activatable probes and advance clinical translations.
Starting Page	646
e-ISSN	20796374
DOI	10.3390/bios12080646
Journal	Biosensors
Issue Number	8
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2022-08-17
Access Restriction	Open
Subject Keyword	Biosensors Aggregation-induced Emission Reactive Oxygen Nitrogen Species Activatable Probe Theranostics Fluorescence Photoacoustic Afterglow Bioimaging
Content Type	Text
Resource Type	Article

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