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Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy
| Content Provider | MDPI |
|---|---|
| Author | Yan, Liang Tan, Yanlian Chen, Guo Fan, Jun Zhang, Jun |
| Copyright Year | 2021 |
| Description | Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of immune cells, particularly in the tumor microenvironment. Understanding how metabolic reprogramming affects both tumor and immune cells, as well as their interplay, is therefore critical to better modulate tumor immune microenvironment in the era of cancer immunotherapy. In this review, we discuss alterations in several essential metabolic pathways in both tumor and key immune cells, provide evidence on their dynamic interaction, and propose innovative strategies to improve cancer immunotherapy via the modulation of metabolic pathways. |
| Starting Page | 10268 |
| e-ISSN | 14220067 |
| DOI | 10.3390/ijms221910268 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 19 |
| Volume Number | 22 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-09-24 |
| Access Restriction | Open |
| Subject Keyword | International Journal of Molecular Sciences Metabolic Reprogramming Tumor Microenvironment Tumor Immune Microenvironment Immune Cells Immunosuppression Immunotherapy |
| Content Type | Text |
| Resource Type | Article |