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Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation
| Content Provider | MDPI |
|---|---|
| Author | Mandel, Jonathan Casari, Martina Stepanyan, Maria Martyanov, Alexey Deppermann, Carsten |
| Copyright Year | 2022 |
| Description | There is accumulating evidence that platelets play roles beyond their traditional functions in thrombosis and hemostasis, e.g., in inflammatory processes, infection and cancer, and that they interact, stimulate and regulate cells of the innate immune system such as neutrophils, monocytes and macrophages. In this review, we will focus on platelet activation in hemostatic and inflammatory processes, as well as platelet interactions with neutrophils and monocytes/macrophages. We take a closer look at the contributions of major platelet receptors GPIb, $α_{IIb}β_{3}$, TLT-1, CLEC-2 and Toll-like receptors (TLRs) as well as secretions from platelet granules on platelet–neutrophil aggregate and neutrophil extracellular trap (NET) formation in atherosclerosis, transfusion-related acute lung injury (TRALI) and COVID-19. Further, we will address platelet–monocyte and macrophage interactions during cancer metastasis, infection, sepsis and platelet clearance. |
| Starting Page | 3868 |
| e-ISSN | 14220067 |
| DOI | 10.3390/ijms23073868 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 7 |
| Volume Number | 23 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-03-31 |
| Access Restriction | Open |
| Subject Keyword | International Journal of Molecular Sciences Hematology Platelets Hemostasis Thrombosis Neutrophils Monocytes Macrophages Inflammation Nets Covid-19 Atherosclerosis Cancer |
| Content Type | Text |
| Resource Type | Article |
