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Molecular Characterization and Phylogenetic Analysis of a Variant Recombinant Porcine Epidemic Diarrhea Virus Strain in China
| Content Provider | MDPI |
|---|---|
| Author | Hu, Xiaoliang Lian, Yuexiao He, Yucan Liu, Xiangxiao Tian, Zhige Dai, Yi Liu, Mengyuan Fan, Huayan Shi, Yue Cong, Feng |
| Copyright Year | 2022 |
| Description | Since 2010, a variant of porcine epidemic diarrhea virus (PEDV) has re-emerged in several provinces of China, resulting in severe economic losses for the pork industry. Here, we isolated and identified a variant PEDV strain, SC-YB73, in Guangdong Province, China. The pathological observations of jejunum showed atrophy of villi and edema in the lamina propria. The sequence analysis of the viral genome identified a six-nucleotide insertion in the E gene, which has not previously been detected in PEDV strains. Furthermore, 50 nucleotide sites were unique in SC-YB73 compared with 27 other PEDV strains. The phylogenetic analysis based on the complete genome showed that SC-YB73 was clustered in variant subgroup GII-a, which is widely prevalent in the Chinese pig population. The recombination analysis suggested that SC-YB73 originated from the recombination of GDS47, US PEDV prototype-like strains TW/Yunlin550/2018, and COL/Cundinamarca/2014. In the present study, we isolated and genetically characterized a variant PEDV strain, thus providing essential information for the control of PED outbreaks in China. |
| Starting Page | 2189 |
| e-ISSN | 20762615 |
| DOI | 10.3390/ani12172189 |
| Journal | Animals |
| Issue Number | 17 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-08-25 |
| Access Restriction | Open |
| Subject Keyword | Animals Virology Porcine Epidemic Diarrhea Virus Variant Insertion Pathogenicity E Gene |
| Content Type | Text |
| Resource Type | Article |
