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Evaluating the Effect of Lignocellulose-Derived Microbial Inhibitors on the Growth and Lactic Acid Production by Bacillus coagulans Azu-10
| Content Provider | MDPI |
|---|---|
| Author | Abdel-Rahman, Mohamed Hassan, Saad Fouda, Amr Radwan, Ahmed Barghoth, Mohammed Desouky, Salha |
| Copyright Year | 2021 |
| Description | Effective lactic acid (LA) production from lignocellulosic biomass materials is challenged by several limitations related to pentose sugar utilization, inhibitory compounds, and/or fermentation conditions. In this study, a newly isolated Bacillus coagulans strain Azu-10 was obtained and showed homofermentative LA production from xylose with optimal fermentation conditions at 50 °C and pH 7.0. Growth of strain Azu-10 and LA-fermentation efficiency were evaluated in the presence of various lignocellulose-derived inhibitors (furans, carboxylic acids, and phenols) at different concentrations. Furanic lignocellulosic-derived inhibitors were completely detoxified. The strain has exhibited high biomass, complete xylose consumption, and high LA production in the presence of 1.0‒4.0 g/L furfural and 1.0‒5.0 g/L of hydroxymethyl furfural, separately. Moreover, strain Azu-10 exhibited high LA production in the presence of 5.0–15.0 g/L acetic acid, 5.0 g/L of formic acid, and up to 7.0 g/L of levulinic acid, separately. Besides, for phenolic compounds, p-coumaric acid was most toxic at 1.0 g/L, while syringaldehyde or p-hydroxybenzaldehyde, and vanillin at 1.0 g/L did not inhibit LA fermentation. The present study provides an interesting potential candidate for the thermophilic LA fermentation from lignocellulose-derived substrates at the industrial biorefinery level. |
| Starting Page | 17 |
| e-ISSN | 23115637 |
| DOI | 10.3390/fermentation7010017 |
| Journal | Fermentation |
| Issue Number | 1 |
| Volume Number | 7 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-01-27 |
| Access Restriction | Open |
| Subject Keyword | Fermentation Paper and Wood Lactic Acid Lignocellulose-inhibitors Furans Bacillus Coagulans Xylose Thermophilic Fermentation |
| Content Type | Text |
| Resource Type | Article |
