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Secondary Metabolites from Hericium erinaceus and Their Anti-Inflammatory Activities
| Content Provider | MDPI |
|---|---|
| Author | Xie, Guangbo Tang, Lan Xie, Yu Xie, Liyuan |
| Copyright Year | 2022 |
| Description | Hericium erinaceus, a culinary and medicinal mushroom, is widely consumed in Asian countries. Chemical investigation on the fruiting bodies of Hericium erinaceus led to the isolation of one new ergostane-type sterol fatty acid ester, erinarol K (1); and eleven known compounds: 5α,8α -epidioxyergosta-6,22-dien-3β-yl linoleate (2); ethyl linoleate (3); linoleic acid (4); hericene A (5); hericene D (6); hericene E (7); ergosta-4,6,8(14),22-tetraen-3-one (8); hericenone F (9); ergosterol (10); ergosterol peroxide (11); 3β,5α,6α,22E-ergosta-7,22-diene-3,5,6-triol 6-oleate (12). The chemical structures of the compounds were determined by 1D and 2D NMR (nuclear magnetic resonance) spectroscopy, mass spectra, etc. Anti-inflammatory effects of the isolated aromatic compounds (5–7, 9) were evaluated in terms of inhibition of pro-inflammatory mediator (TNF-α, IL-6 and NO) production in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. The results showed that compounds 5 and 9 exhibited moderate activity against TNF-α $(IC_{50}$: 78.50 μM and 62.46 μM), IL-6 $(IC_{50}$: 56.33 μM and 48.50 μM) and NO $(IC_{50}$: 87.31 μM and 76.16 μM) secretion. These results supply new information about the secondary metabolites of Hericium erinaceus and their anti-inflammatory effects. |
| Starting Page | 2157 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules27072157 |
| Journal | Molecules |
| Issue Number | 7 |
| Volume Number | 27 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-03-27 |
| Access Restriction | Open |
| Subject Keyword | Molecules Integrative and Complementary Medicine Hericium Erinaceus Secondary Metabolites Isolation and Structural Elucidation Anti-inflammatory Activity |
| Content Type | Text |
| Resource Type | Article |
