Loading...
Please wait, while we are loading the content...
Similar Documents
Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization
| Content Provider | MDPI |
|---|---|
| Author | Luk, áš Žid Vladim, ír Zeleňák Miroslav, Almáši Adriana, Zeleňáková Jaroslava, Szücsová Jozef, Bednarčík Monika, Šuleková Alexander, Hudák Lucia, Váhovská |
| Copyright Year | 2020 |
| Description | In this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal anti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with 3-aminopropyl, phenyl and cyclohexyl groups by grafting method. Naproxen was adsorbed into pores of the prepared MPS from ethanol solution using a solvent evaporation method. The release of the drug was performed in buffer medium at pH 2 and physiological solution at pH 7.4. Parent MPSs as well as naproxen loaded MPSs were characterized using physicochemical techniques such as nitrogen adsorption/desorption, thermogravimetric analysis (TG), Zeta potential analysis, Fourier transform infrared spectroscopy (FT-IR), and elemental analysis. The amount of naproxen released from the MPSs into the medium was determined by high-performance liquid chromatography (HPLC). It was shown that the adsorption and desorption characteristics of naproxen are dependent on the pH of the solution and the surface functionalization of the host. |
| Starting Page | 4722 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules25204722 |
| Journal | Molecules |
| Issue Number | 20 |
| Volume Number | 25 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-10-15 |
| Access Restriction | Open |
| Subject Keyword | Molecules Drug Delivery System Nanomaterials Mesoporous Silica Naproxen Prolonged Release |
| Content Type | Text |
| Resource Type | Article |
