NDLI: Carica papaya Leaf Juice for Dengue: A Scoping Review

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Carica papaya Leaf Juice for Dengue: A Scoping Review

Content Provider	MDPI
Author	Teh, Bee Ping Ahmad, Norzahirah Binti Mohamad, Saharuddin Bin Tan, Terence Yew Chin Razak, Mohd Ridzuan Bin Mohd Abd Afzan, Adlin Binti Mohamed, Ami Fazlin Binti Syed
Copyright Year	2022
Description	The potential therapeutic effect of Carica papaya leaf juice has attracted wide interest from the public and scientists in relieving dengue related manifestations. Currently, there is a lack of evaluated evidence on its juice form. Therefore, this scoping review aims to critically appraise the available scientific evidence related to the efficacy of C. papaya leaf juice in dengue. A systematic search was performed using predetermined keywords on two electronic databases (PubMed and Google Scholar). Searched results were identified, screened and appraised to establish the association between C. papaya and alleviating dengue associated conditions. A total of 28 articles (ethnobotanical information: three, in vitro studies: three, ex vivo studies: one, in vivo study: 13, clinical studies: 10) were included for descriptive analysis, which covered study characteristics, juice preparation/formulations, study outcomes, and toxicity findings. Other than larvicidal activity, this review also reveals two medicinal potentials of C. papaya leaf juice on dengue infection, namely anti-thrombocytopenic and immunomodulatory effects. C. papaya leaf juice has the potential to be a new drug candidate against dengue disease safely and effectively.
Starting Page	1584
e-ISSN	20726643
DOI	10.3390/nu14081584
Journal	Nutrients
Issue Number	8
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2022-04-11
Access Restriction	Open
Subject Keyword	Nutrients Integrative and Complementary Medicine Carica Papaya Papaya Leaf Juice Dengue Platelet Phenolic Flavonoid
Content Type	Text
Resource Type	Article

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