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Innate Immune Responses to Herpesvirus Infection
| Content Provider | MDPI |
|---|---|
| Author | O’Connor, Christine M. Sen, Ganes C. |
| Copyright Year | 2021 |
| Description | Infection of a host cell by an invading viral pathogen triggers a multifaceted antiviral response. One of the most potent defense mechanisms host cells possess is the interferon (IFN) system, which initiates a targeted, coordinated attack against various stages of viral infection. This immediate innate immune response provides the most proximal defense and includes the accumulation of antiviral proteins, such as IFN-stimulated genes (ISGs), as well as a variety of protective cytokines. However, viruses have co-evolved with their hosts, and as such, have devised distinct mechanisms to undermine host innate responses. As large, double-stranded DNA viruses, herpesviruses rely on a multitude of means by which to counter the antiviral attack. Herein, we review the various approaches the human herpesviruses employ as countermeasures to the host innate immune response. |
| Starting Page | 2122 |
| e-ISSN | 20734409 |
| DOI | 10.3390/cells10082122 |
| Journal | Cells |
| Issue Number | 8 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-08-18 |
| Access Restriction | Open |
| Subject Keyword | Cells Virology Herpesvirus Hsv Hcmv Kshv Innate Immune Response Antiviral Host Response Intrinsic Immunity Innate Immunity |
| Content Type | Text |
| Resource Type | Article |
