NDLI: Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial

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Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial

Content Provider	MDPI
Author	Kawano, Takanori Naito, Junko Nishioka, Machiko Nishida, Norihisa Takahashi, Madoka Kashiwagi, Shinichi Sugino, Tomohiro Watanabe, Yasuyoshi
Copyright Year	2020
Description	Euglena gracilis EOD-1, a kind of microalgae, is known to contain a high proportion of paramylon, a type of β-1,3-glucan. Paramylon derived from E. gracilis EOD-1 is presumed to suppress cellular oxidative injury and expected to reduce fatigue and fatigue sensation. Therefore, we aimed to examine whether food containing paramylon derived from E. gracilis EOD-1 (EOD-1PM) ingestion reduced fatigue and fatigue sensation in healthy adults. We conducted a randomized, double-blind, placebo-controlled, parallel-group comparison study in 66 healthy men and women who ingested a placebo or EOD-1PM daily for 4 weeks (daily life fatigue). Furthermore, at the examination days of 0 and 4 weeks, tolerance to fatigue load was evaluated using mental tasks (task-induced fatigue). We evaluated fatigue sensation using the Visual Analogue Scale, the work efficiency of the advanced trail making test and measured serum antioxidant markers. The EOD-1PM group showed significantly lower levels of physical and mental fatigue sensations and higher levels of work efficiency as well as serum biological antioxidant potential levels than the placebo group. These results indicate that EOD-1PM ingestion reduced fatigue and fatigue sensation, which may be due to an increase in antioxidant potential and maintenance of selective attention during work.
Starting Page	3098
e-ISSN	20726643
DOI	10.3390/nu12103098
Journal	Nutrients
Issue Number	10
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2020-10-12
Access Restriction	Open
Subject Keyword	Nutrients Integrative and Complementary Medicine Euglena Gracilis Eod-1 Β-glucan Paramylon Fatigue Selective Attention Antioxidant
Content Type	Text
Resource Type	Article

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