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Systematic Investigations on Continuous Fluidized Bed Crystallization for Chiral Separation
| Content Provider | MDPI |
|---|---|
| Author | Jonathan, Gänsch Temmel, Erik Seidel-Morgenstern, Andreas Lorenz, Heike |
| Copyright Year | 2020 |
| Description | A recently developed continuous enantioseparation process utilizing two coupled fluidized bed crystallizers is systematically investigated to identify essential correlations between different operation parameters and the corresponding process performance on the example of asparagine monohydrate. Based on liquid phase composition and product crystal size distribution data, it is proven that steady state operation is achieved reproducibly in a relatively short time. The process outputs at steady state are compared for different feed flow rates, supersaturations, and crystallization temperatures. It is shown that purities >97% are achieved with productivities up to 40 g/L/h. The size distribution, which depends almost exclusively on the liquid flow rate, can be easily adjusted between 260 and 330 µm (mean size) with an almost constant standard deviation of ±55 µm. |
| Starting Page | 394 |
| e-ISSN | 20734352 |
| DOI | 10.3390/cryst10050394 |
| Journal | Crystals |
| Issue Number | 5 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-05-14 |
| Access Restriction | Open |
| Subject Keyword | Crystals Manufacturing Engineering Fluidized Bed Continuous Preferential Crystallization Chiral Separation Racemate Resolution Enantiomer Asparagine Monohydrate |
| Content Type | Text |
| Resource Type | Article |
