NDLI: Tumor Suppressive Effects of GAS5 in Cancer Cells

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Tumor Suppressive Effects of GAS5 in Cancer Cells

Content Provider	MDPI
Author	Kaur, Jesminder Salehen, Nur’Ain Norazit, Anwar Rahman, Amirah Abdul Murad, Nor Azian Abdul Rahman, Nik Mohd Afizan Nik Abd. Ibrahim, Kamariah
Copyright Year	2022
Description	In recent years, long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cellular processes. Growth arrests specific transcript 5 (GAS5) is a lncRNA that is highly expressed during the cell cycle arrest phase but is downregulated in actively growing cells. Growth arrests specific transcript 5 was discovered to be downregulated in several cancers, primarily solid tumors, and it is known as a tumor suppressor gene that regulates cell proliferation, invasion, migration, and apoptosis via multiple molecular mechanisms. Furthermore, GAS5 polymorphism was found to affect GAS5 expression and functionality in a cell-specific manner. This review article focuses on GAS5’s tumor-suppressive effects in regulating oncogenic signaling pathways, cell cycle, apoptosis, tumor-associated genes, and treatment-resistant cells. We also discussed genetic polymorphisms of GAS5 and their association with cancer susceptibility.
Starting Page	39
e-ISSN	2311553X
DOI	10.3390/ncrna8030039
Journal	Non-Coding RNA
Issue Number	3
Volume Number	8
Language	English
Publisher	MDPI
Publisher Date	2022-05-28
Access Restriction	Open
Subject Keyword	Non-Coding RNA Non-coding Rna Oncology Lncrna Growth-arrest Specific Transcript 5 Gas5 Tumor Suppressor Polymorphism
Content Type	Text
Resource Type	Article

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