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Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida
| Content Provider | MDPI |
|---|---|
| Author | Chy, Alam, Najmul Banu, Naureen Aziz, Arfin Barua, Niloy Ruman, Umme Jahan, Israt Chy, Farhana Denath, Susmita Paul, Arkajyoti Sayeed, Mohammed Emran, Talha Simal-Gandara, Jesus |
| Copyright Year | 2021 |
| Description | Sterculia foetida, also known as jangli badam in Bangladesh, is a traditionally used plant that has pharmacological activities. A qualitative phytochemical analysis was performed to assess the metabolites in a methanolic extract of S. foetida seeds (MESF), and the cytotoxic, thrombolytic, anti-arthritics, analgesic, and antipyretic activities were examined using in vitro, in vivo, and in silico experiments. Quantitative studies were performed through gas chromatography-mass spectroscopy (GC-MS) analysis. The brine shrimp lethality bioassays and clot lysis were performed to investigate the cytotoxic and thrombolytic activities, respectively. The anti-arthritics activity was assessed using the albumin denaturation assay. Analgesic activity was determined using the acetic acid-induced writhing test and the formalin-induced paw-licking test. A molecular docking study was performed, and an online tool was used to perform ADME/T (absorption, distribution, metabolism, and excretion/toxicity) and PASS (Prediction of Activity Spectra for Substances). GC-MS analysis identified 29 compounds in MESF, consisting primarily of phenols, terpenoids, esters, and other organic compounds. MESF showed moderate cytotoxic activity against brine shrimp and significant thrombolytic and anti-arthritics activities compared with the relative standards. The extract also showed a dose-dependent and significant analgesic and antipyretic activities. Docking studies showed that 1-azuleneethanol, acetate returned the best scores for the tested enzymes. These findings suggested that MESF represents a potent source of thrombolytic, anti-arthritic, analgesic, antipyretic agents with moderate cytotoxic effects. |
| Starting Page | 1135 |
| e-ISSN | 22237747 |
| DOI | 10.3390/plants10061135 |
| Journal | Plants |
| Issue Number | 6 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-06-03 |
| Access Restriction | Open |
| Subject Keyword | Plants Integrative and Complementary Medicine Sterculia Foetida Gc-ms Cytotoxic Thrombolytic Analgesic Antipyretic Molecular Docking |
| Content Type | Text |
| Resource Type | Article |
