NDLI: SARS-CoV-2 in Urine May Predict a Severe Evolution of COVID-19

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SARS-CoV-2 in Urine May Predict a Severe Evolution of COVID-19

Content Provider	MDPI
Author	Perrella, Alessandro Brita, Mario Coletta, Francesco Cotena, Simona Marco, Giampaola De Longobardi, Adele Sala, Crescenzo Sannino, Dania Tomasello, Antonio Perrella, Marco Russo, Giuseppe Tarsitano, Marina Chetta, Massimo Monica, Matteo Della Orlando, Valentina Coscioni, Enrico Villani, Romolo
Copyright Year	2021
Description	We hypothesized that the spread of SARS-CoV-2 in urine during a severe COVID-19 infection may be the expression of the worsening disease evolution. Therefore, the aim of this study was to verify if the COVID-19 disease severity is related to the viral presence in urine samples. We evaluated the clinical evolution in acute COVID-19 patients admitted in the sub-intensive care and intensive care units between 28 of December 2020 and 15th of February 2021 and being positive for SARS-CoV-2 RNA in the respiratory tract, including repeated endotracheal aspirates (ETA), sputum, nasopharyngeal swabs (NPS) and urine. We found that those subjects with SARS-COV-2 in the urine at admittance (8 out of 60 eligible patients) had a more severe disease than those with negative SARS-CoV-2 in urine. Further, they showed an increase in fibrinogen and (C-reactive Protein) CRP serum levels, requiring mechanic ventilation. Of those with positive SARS-CoV-2 in the urine, 50% died. According to our preliminary results, it seems that the presence of SARS-CoV-2 in the urine characterizes patients with a more severe disease and is also related to a higher death rate.
Starting Page	4061
e-ISSN	20770383
DOI	10.3390/jcm10184061
Journal	Journal of clinical medicine
Issue Number	18
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-09-08
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Infectious Diseases Covid-19 Sars-cov-2 Unusual Covid Atypical Covid-19 Sars-cov-2 Urine
Content Type	Text
Resource Type	Article

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