Loading...
Please wait, while we are loading the content...
Similar Documents
Serum Perilipin 2 (PLIN2) Predicts Multiple Organ Dysfunction in Critically Ill Patients
| Content Provider | MDPI |
|---|---|
| Author | Kurt, Berkan Buendgens, Lukas Wirtz, Theresa H. Loosen, Sven H. Schulze-Hagen, Maximilian Truhn, Daniel Brozat, Jonathan F. Jhaisha, Samira Abu Hohlstein, Philipp Koek, Ger Weiskirchen, Ralf Trautwein, Christian Tacke, Frank Hamesch, Karim Koch, Alexander |
| Copyright Year | 2021 |
| Description | Perilipin 2 (PLIN2) is a lipid droplet protein with various metabolic functions. However, studies investigating PLIN2 in the context of inflammation, especially in systemic and acute inflammation, are lacking. Hence, we assessed the relevance of serum PLIN2 in critically ill patients. We measured serum PLIN2 serum in 259 critically ill patients (166 with sepsis) upon admission to a medical intensive care unit (ICU) compared to 12 healthy controls. A subset of 36 patients underwent computed tomography to quantify body composition. Compared to controls, serum PLIN2 concentrations were elevated in critically ill patients at ICU admission. Interestingly, PLIN2 independently indicated multiple organ dysfunction (MOD), defined as a SOFA score > 9 points, at ICU admission, and was also able to independently predict MOD after 48 h. Moreover, serum PLIN2 levels were associated with severe respiratory failure potentially reflecting a moribund state. However, PLIN2 was neither a predictor of ICU mortality nor did it reflect metabolic dysregulation. Conclusively, the first study assessing serum PLIN2 in critical illness proved that it may assist in risk stratification because it is capable of independently indicating MOD at admission and predicting MOD 48 h after PLIN2 measurement. Further evaluation regarding the underlying mechanisms is warranted. |
| Starting Page | 1210 |
| e-ISSN | 22279059 |
| DOI | 10.3390/biomedicines9091210 |
| Journal | Biomedicines |
| Issue Number | 9 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-09-13 |
| Access Restriction | Open |
| Subject Keyword | Biomedicines Anesthesiology Sepsis Critical Illness Intensive Care Unit Biomarker Sofa Prognosis Outcome Organ Failure |
| Content Type | Text |
| Resource Type | Article |
