NDLI: Citral-Containing Essential Oils as Potential Tyrosinase Inhibitors: A Bio-Guided Fractionation Approach

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Citral-Containing Essential Oils as Potential Tyrosinase Inhibitors: A Bio-Guided Fractionation Approach

Content Provider	MDPI
Author	Capetti, Francesca Tacchini, Massimo Marengo, Arianna Cagliero, Cecilia Bicchi, Carlo Rubiolo, Patrizia Sgorbini, Barbara
Copyright Year	2021
Description	Excessive melanin production causes serious dermatological conditions as well as minor aesthetic problems (i.e., freckles and solar lentigo). The downregulation of tyrosinase is a widespread approach for the treatment of such disorders, and plant extracts have often proven to be valuable sources of tyrosinase inhibitors. Citral (a mixture of neral and geranial) is an important fragrance ingredient that has shown anti-tyrosinase potential. It is highly concentrated in the essential oils (EOs) of Cymbopogon schoenanthus (L.) Spreng., Litsea c뺺 (Lour.) Pers., Melissa officinalis L., and Verbena officinalis L. However, only L. c뺺 EO has been investigated for use as a potential skin-whitening agent. This work evaluates the in vitro tyrosinase inhibitory activity of these EOs and studies, using bio-assay oriented fractionation, whether their differing chemical compositions influence the overall EO inhibitory activities via possible synergistic, additive, and/or competitive interactions between EOs components. The inhibitory activity of C. schoenanthus EO and that of M. officinalis EOs, with negligible (+)-citronellal amounts, were in-line with their citral content. On the other hand, L. c뺺 and V. officinalis EOs inhibited tyrosinase to considerably greater extents as they contained β-myrcene, which contributed to the overall EO activities. Similar observations were made for M. officinalis EO, which bears high (+)-citronellal content which increased citral activity.
Starting Page	969
e-ISSN	22237747
DOI	10.3390/plants10050969
Journal	Plants
Issue Number	5
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-05-13
Access Restriction	Open
Subject Keyword	Plants Integrative and Complementary Medicine Tyrosinase Inhibition Essential Oils Citral
Content Type	Text
Resource Type	Article

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