NDLI: Evaluation of Composition Effects on the Physicochemical and Biological Properties of Polypeptide-Based Hydrogels for Potential Application in Wound Healing

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Evaluation of Composition Effects on the Physicochemical and Biological Properties of Polypeptide-Based Hydrogels for Potential Application in Wound Healing

Content Provider	MDPI
Author	Giliomee, Johnel du Toit, Lisa Kumar, Pradeep Klumperman, Bert Choonara, Yahya
Copyright Year	2021
Description	In this study, the effect of crosslinking and concentration on the properties of a new library of low-concentration $poly(Lys_{60}-ran-Ala_{40}$)-based hydrogels for potential application in wound healing was investigated in order to correlate the hydrogel composition with the desired physicochemical and biofunctional properties to expand the assortment of poly-l-lysine (PLL)-based hydrogels suitable for wound healing. Controlled ring-opening polymerization (ROP) and precise hydrogel compositions were used to customize the physicochemical and biofunctional properties of a library of new hydrogels comprising poly(l-lysine-ran-l-alanine) and four-arm poly(ethylene glycol) (P(KA)/4-PEG). The chemical composition and degree of crosslinking via free amine quantification were analyzed for the P(KA)/4-PEG hydrogels. In addition, the rheological properties, pore morphology, swelling behavior and degradation time were characterized. Subsequently, in vitro cell studies for evaluation of the cytotoxicity and cell adhesion were performed. The 4 wt% 1:1 functional molar ratio hydrogel with P(KA) concentrations as low as 0.65 wt% demonstrated low cytotoxicity and desirable cell adhesion towards fibroblasts and thus displayed a desirable combination of properties for wound healing application.
Starting Page	1828
e-ISSN	20734360
DOI	10.3390/polym13111828
Journal	Polymers
Issue Number	11
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-05-31
Access Restriction	Open
Subject Keyword	Polymers Textiles Polypeptide-based Hydrogel Wound Healing Ring-opening Polymerization Poly-l-lysine 4-arm Poly(ethylene Glycol)
Content Type	Text
Resource Type	Article

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