NDLI: Pancreatic Cancer and Gut Microbiome-Related Aspects: A Comprehensive Review and Dietary Recommendations

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Pancreatic Cancer and Gut Microbiome-Related Aspects: A Comprehensive Review and Dietary Recommendations

Content Provider	MDPI
Author	Karolina, Kaźmierczak-Siedlecka Viktoria, Hawryłkowicz Sobocki, Bartosz Kamil Folwarski, Marcin Makarewicz, Wojciech Stachowska, Ewa
Copyright Year	2021
Description	Gut microbiota plays a significant role in the human body providing many beneficial effects on the host. However, its dysbiotic alterations may affect the tumorigenic pathway and then trigger the development of pancreatic cancer. This dysbiosis can also modulate the aggressiveness of the tumor, influencing the microenvironment. Because pancreatic cancer is still one of the most lethal cancers worldwide with surgery as the only method that influences prognosis and has curative potential, there is a need to search for other strategies which will enhance the efficiency of standard therapy and improve patients’ quality of life. The administration of prebiotics, probiotics, next-generation probiotics (Faecalibacterium prausnitzii, Akkermansia muciniphila), synbiotics, postbiotics, and fecal microbiota transplantation through multiple mechanisms affects the composition of the gut microbiota and may restore its balance. Despite limited data, some studies indicate that the aforementioned methods may allow to achieve better effect of pancreatic cancer treatment and improve therapeutic strategies for pancreatic cancer patients.
Starting Page	4425
e-ISSN	20726643
DOI	10.3390/nu13124425
Journal	Nutrients
Issue Number	12
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-12-10
Access Restriction	Open
Subject Keyword	Nutrients Pancreatic Cancer Gut Microbiota Prebiotics Probiotics Next-generation Probiotics Synbiotics Postbiotics Fecal Microbiota Transplantation
Content Type	Text
Resource Type	Article

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