Loading...
Please wait, while we are loading the content...
Similar Documents
Emerging Roles of Long Noncoding RNAs in the Cytoplasmic Milieu
| Content Provider | MDPI |
|---|---|
| Author | Aillaud, Michelle Schulte, Leon N. |
| Copyright Year | 2020 |
| Description | While the important functions of long noncoding RNAs (lncRNAs) in nuclear organization are well documented, their orchestrating and architectural roles in the cytoplasmic environment have long been underestimated. However, recently developed fractionation and proximity labelling approaches have shown that a considerable proportion of cellular lncRNAs is exported into the cytoplasm and associates nonrandomly with proteins in the cytosol and organelles. The functions of these lncRNAs range from the control of translation and mitochondrial metabolism to the anchoring of cellular components on the cytoskeleton and regulation of protein degradation at the proteasome. In the present review, we provide an overview of the functions of lncRNAs in cytoplasmic structures and machineries und discuss their emerging roles in the coordination of the dense intracellular milieu. It is becoming apparent that further research into the functions of these lncRNAs will lead to an improved understanding of the spatiotemporal organization of cytoplasmic processes during homeostasis and disease. |
| Starting Page | 44 |
| e-ISSN | 2311553X |
| DOI | 10.3390/ncrna6040044 |
| Journal | Non-Coding RNA |
| Issue Number | 4 |
| Volume Number | 6 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-11-09 |
| Access Restriction | Open |
| Subject Keyword | Non-Coding RNA Non-coding Rna Physiology Long Noncoding Rna Lncrna Cytoplasm Cytosol Translation Organelles Phase-separation |
| Content Type | Text |
| Resource Type | Article |
