NDLI: Amaryllidaceae, Lycopodiaceae Alkaloids and Coumarins—A Comparative Assessment of Safety and Pharmacological Activity

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Amaryllidaceae, Lycopodiaceae Alkaloids and Coumarins—A Comparative Assessment of Safety and Pharmacological Activity

Content Provider	MDPI
Author	Iwona, Piątkowska-Chmiel Kamil, Pawłowski Herbet, Mariola Widelski, Jarosław Dymek, Aleksandra Mroczek, Tomasz
Copyright Year	2022
Description	The study aimed to evaluate the safety and pharmacological activity Amaryllidaceae, Lycopodiaceae alkaloids and coumarins obtained from Narcissus triandrus L., Lycopodium clavatum L., Lycopodium annotinum L., Huperzia selago L. and Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. In the in vivo studies. The influence of the tested compounds on the central nervous system of rats was assessed in behavioral tests (locomotor activity, Y-maze, passive avoidance). In order to investigate the mechanisms of action, biochemical determinations were performed (AChE activity, BChE activity, IL-1β, IL-6 concentration). In order to assess safety, the concentrations of AST, ALT, GGT and urea and creatinine were determined. The results of the conducted studies indicate a high safety profile of the tested compounds. Behavioral tests showed that they significantly improved rodent memory in a passive avoidance test. The results of biochemical studies showed that by reducing the activity of AChE and BChE and lowering the concentration of IL-1β and IL-6, the coumarin-rich Angelica dahurica extract shows the most promising potential for future therapeutic AD strategies.
Starting Page	4291
e-ISSN	20770383
DOI	10.3390/jcm11154291
Journal	Journal of clinical medicine
Issue Number	15
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2022-07-23
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Integrative and Complementary Medicine Alzheimer's Disease Amaryllidaceae Alkaloids Lycopodiaceae Alkaloids Coumarins Acetylcholinesterase Inhibitors Inflammation
Content Type	Text
Resource Type	Article

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