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Synthesis of 1-(2-Fluorophenyl)pyrazoles by 1,3-Dipolar Cycloaddition of the Corresponding Sydnones
| Content Provider | MDPI |
|---|---|
| Author | Dumitrescu, Denisa Shova, Sergiu Draghici, Constantin Popa, Marcel Dumitrascu, Florea |
| Copyright Year | 2021 |
| Description | 3-Arylsydnones bearing fluorine and bromine atoms on the benzene ring were synthesized from N-nitroso-2-fluorophenylglycines and characterized by NMR spectroscopy. These were employed further in synthesis of the corresponding 1-(2-fluorophenyl)pyrazoles by 1,3-dipolar cycloaddition reaction with dimethyl acetylenedicarboxylate (DMAD) as activated dipolarophile. The sydnones as reaction intermediates were characterized by single crystal X-ray diffraction analysis showing interesting features such as halogen bonding as an important interaction in modeling the crystal structure. |
| Starting Page | 3693 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules26123693 |
| Journal | Molecules |
| Issue Number | 12 |
| Volume Number | 26 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-06-17 |
| Access Restriction | Open |
| Subject Keyword | Molecules Organic Chemistry Sydnone 1,3-dipolar Cycloaddition Pyrazole X-ray Diffraction Halogen Bonding |
| Content Type | Text |
| Resource Type | Article |
