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The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM)
| Content Provider | MDPI |
|---|---|
| Author | Melocchi, Alice Uboldi, Marco Briatico-Vangosa, Francesco Moutaharrik, Saliha Cerea, Matteo Foppoli, Anastasia Maroni, Alessandra Palugan, Luca Zema, Lucia Gazzaniga, Andrea |
| Copyright Year | 2021 |
| Description | The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting configuration, entailing a gastroresistant film to prevent early interaction of the inner coat with gastric fluids and enabling the attainment of a lag phase matching the small intestinal transit time. Over the years, various multiple-step manufacturing processes have been tested for the fabrication of the Chronotopic™ system in both its configurations. This work focused on the evaluation of 3D printing by fused deposition modeling in view of its potential towards product personalization, on demand one-step manufacturing and efficient scale down of batches. The feasibility of each part of the Chronotopic™ system was independently investigated starting from in-house made filaments, characterizing the resulting specimens for physico-technological and performance characteristics. The printing parameters identified as suitable during the set-up phase were then used to fabricate prototypes either in a single step for the pulsatile configuration or following two different fabrication approaches for the colon-targeting one. |
| Starting Page | 759 |
| e-ISSN | 19994923 |
| DOI | 10.3390/pharmaceutics13050759 |
| Journal | Pharmaceutics |
| Issue Number | 5 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-05-20 |
| Access Restriction | Open |
| Subject Keyword | Pharmaceutics Manufacturing Engineering 3d Printing Fused Deposition Modeling Multi-component Systems Chronopharmaceutics Controlled Release Pulsatile Release Colon Targeting |
| Content Type | Text |
| Resource Type | Article |
