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Association of Dietary Vitamin D Intake, Serum $25(OH)D_{3}$, $25(OH)D_{2}$ with Cognitive Performance in the Elderly
| Content Provider | MDPI |
|---|---|
| Author | Wang, Rutong Wang, Weijing Hu, Ping Zhang, Ronghui Dong, Xue Zhang, Dongfeng |
| Copyright Year | 2021 |
| Description | Background: As life expectancy increases, cognitive performance decline in the elderly has become one of the major global challenges. We aimed to evaluate the association of dietary vitamin D (VD), serum 25-hydroxyvitamin D3 $(25(OH)D_{3}$), 25-hydroxyvitamin D2 $(25(OH)D_{2}$), and total 25-hydroxyvitamin (25(OH)D) concentration with cognitive performance in older Americans. Methods: The data from the National Health and Nutrition Examination Survey (NHANES), 2011–2014 was used. The cognitive performance was assessed by the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Word Learning sub-test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). A binary logistic regression model was applied to evaluate the association between VD and cognitive performance, and restricted cubic spline model was adopted to evaluate the dose–response relationship. Results: While comparing to the lowest dietary VD intake group, the multivariate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of the highest dietary VD intake group were 0.51 (0.36–0.72) for the Animal Fluency test score and 0.45 (0.31–0.66) for DSST score, respectively; and those of serum total 25(OH)D and $25(OH)D_{3}$ concentration were 0.68 (0.47–0.97) and 0.62 (0.44–0.86) for DSST score. L-shaped relationships were identified for dietary VD intake, serum total 25(OH)D and $25(OH)D_{3}$ concentration with cognition performance. The associations between dietary VD intake, serum total 25(OH)D and cognitive performance were non-significant when stratified by gender. Conclusions: The study indicates that dietary VD intake, serum total 25(OH)D and $25(OH)D_{3}$ concentration were positively associated with cognitive performance. Further studies are needed to clarify the possible effects of dietary VD intake and serum $25(OH)D_{2}$, $25(OH)D_{3}$ on cognitive performance. |
| Starting Page | 3089 |
| e-ISSN | 20726643 |
| DOI | 10.3390/nu13093089 |
| Journal | Nutrients |
| Issue Number | 9 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-09-02 |
| Access Restriction | Open |
| Subject Keyword | Nutrients Nutrition and Dietetics Cognitive Performance Dietary Vitamin D 25-hydroxyvitamin D3 25-hydroxyvitamin D2 Does–response |
| Content Type | Text |
| Resource Type | Article |
