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Chronic Bronchitis Affects Outcomes in Smokers without Chronic Obstructive Pulmonary Disease (COPD)
| Content Provider | MDPI |
|---|---|
| Author | Mariaenrica, Tinè Casara, Alvise Turato, Graziella Marin-Oto, Marta Semenzato, Umberto Biondini, Davide Bernardinello, Nicol Cocconcelli, Elisabetta Cubero, Pablo Balestro, Elisabetta Spagnolo, Paolo Marin, Josè M. Cosio, Manuel G. Saetta, Marina Bazzan, Erica |
| Copyright Year | 2022 |
| Description | Background. Chronic bronchitis (CB) importantly affects outcomes in smokers with COPD, but the effects on smokers without COPD are less well known and less emphasized. The aim of our study was to investigate the possible effects of CB on clinical outcomes in smokers without COPD (noCOPD) and compare them with the effects in smokers with COPD (COPD). Methods. For that purpose, we studied 511 smokers, 302 with and 209 without COPD, followed for 10 years in an academic COPD ambulatory setting. Chronic bronchitis was defined as the presence of cough and sputum production for at least 3 months in each of two consecutive years. All subjects underwent clinical and functional examination with spirometry, diffusion capacity (DLco), 6-min walking test (6MWT), mMRC Dyspnoea Scale, COPD Assessment Test (CAT), and recording of annual frequency of exacerbations. All-cause mortality during follow-up was recorded. Results. 27% of noCOPD and 45% of COPD had CB. noCOPD with CB had lower $FEV_{1}$ and DLco, worse 6MWT, more dyspnoea, a higher number of exacerbations and lower survival than noCOPD without CB. CB did not affect $FEV_{1}$ decline in noCOPD but it significantly did in COPD. Conclusions. The presence of chronic bronchitis in smokers without COPD will significantly affect symptoms, quality of life, and survival, underlining the importance of recognizing the condition and managing it accordingly. |
| Starting Page | 4886 |
| e-ISSN | 20770383 |
| DOI | 10.3390/jcm11164886 |
| Journal | Journal of clinical medicine |
| Issue Number | 16 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-08-20 |
| Access Restriction | Open |
| Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Respiratory System Chronic Bronchitis Copd Smoking |
| Content Type | Text |
| Resource Type | Article |
