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Comparison of Rapid and Automated Antigen Detection Tests for the Diagnosis of SARS-CoV-2 Infection
| Content Provider | MDPI |
|---|---|
| Author | Petonnet, Dorian Marot, Stéphane Leroy, Isabelle Cohier, Julien Ramahefasolo, Charline Mansaly, Safietou Calvez, Vincent Marcelin, Anne-Geneviève Burrel, Sonia |
| Copyright Year | 2022 |
| Description | SARS-CoV-2 viral antigen detection may be an interesting alternative to RT-PCR for the diagnosis of SARS-CoV-2 infection as a less laborious or expensive method but requires validation. This study aimed to compare the performance of the DiaSorin™ LiaisonXL automated quantitative antigen test (QAT) and the AAZ™ rapid antigen test (RAT) to the DiaSorin™ MDX RT-PCR assay. A total of 242 nasopharyngeal samples were tested at La Pitié-Salpêtrière University Hospital (Paris, France). Performances for the detection of variants of SARS-CoV-2 were further investigated. RATs were visually read for qualitative results and band intensity was determined. Overall sensitivity was 63.2% for QAT and 58.6% for RAT. For RT-PCR Ct value 25, sensitivity was 89.8% for both tests. Both tests showed comparable sensitivity for detection of variants. There was a strong relationship between antigen concentration and band positivity. On the same set of samples these tests share similar performances. |
| Starting Page | 104 |
| e-ISSN | 20754418 |
| DOI | 10.3390/diagnostics12010104 |
| Journal | Diagnostics |
| Issue Number | 1 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-04 |
| Access Restriction | Open |
| Subject Keyword | Diagnostics Microbiology Covid-19 Sars-cov-2 Antigen Testing Manual Assay Automated Assay Nucleocapsid Diagnostic Nasopharyngeal Swab |
| Content Type | Text |
| Resource Type | Article |
