NDLI: Serum Levels of Fibroblast Growth Factor 21 Are Positively Associated with Aortic Stiffness in Patients with Type 2 Diabetes Mellitus

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Serum Levels of Fibroblast Growth Factor 21 Are Positively Associated with Aortic Stiffness in Patients with Type 2 Diabetes Mellitus

Content Provider	MDPI
Author	Huang, Sin-Yi Wu, Du-An Tsai, Jen-Pi Hsu, Bang-Gee
Copyright Year	2021
Description	Aortic stiffness (AS), assessed using carotid–femoral pulse wave velocity (cfPWV), is associated with cardiovascular disease in type 2 diabetes mellitus (T2DM). The relationship between serum fibroblast growth factor 21 (FGF-21) and AS in T2DM patients was evaluated. Fasting serum FGF-21 levels of 130 T2DM patients were measured using an enzyme immunoassay kit. A validated tonometry system was used to measure cfPWV (>10 m/s indicated AS). Of these T2DM patients, 34.6% were defined as the AS group. T2DM patients with AS were older; exhibited higher systolic blood pressure, diastolic blood pressure, and body fat mass; higher triglyceride, fasting glucose, glycosylated hemoglobin, and creatinine levels; higher urine albumin-to-creatinine ratios and serum FGF-21 levels; and lower estimated glomerular filtration rates. The FGF-21 level (odds ratio = 1.005, 95% confidence interval: 1.002–1.009, p = 0.002) as well as systolic blood pressure was an independent predictor of AS and positively correlated to cfPWV values (β = 0.369, p < 0.001) in T2DM patients. For T2DM patients, serum FGF-21 level could be a predictor for AS.
Starting Page	3434
e-ISSN	16604601
DOI	10.3390/ijerph18073434
Journal	International Journal of Environmental Research and Public Health
Issue Number	7
Volume Number	18
Language	English
Publisher	MDPI
Publisher Date	2021-03-26
Access Restriction	Open
Subject Keyword	International Journal of Environmental Research and Public Health Cardiology and Cardiovascular Diseases Endocrinology and Metabolism Aortic Stiffness Fibroblast Growth Factor 21 Carotid–femoral Pulse Wave Velocity Type 2 Diabetes Mellitus
Content Type	Text
Resource Type	Article

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