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Diagnosis of Indigenous Non-Malarial Vector-Borne Infections from Malaria Negative Samples from Community and Rural Hospital Surveillance in Dhalai District, Tripura, North-East India
| Content Provider | MDPI |
|---|---|
| Author | Bhowmick, Ipsita Pal Pandey, Apoorva Subbarao, Sarala K. Pebam, Rocky Majumder, Tapan Nath, Aatreyee Nandi, Diptarup Basu, Analabha Sarkar, Apurba Majumder, Saikat Debbarma, Jotish Dasgupta, Dipanjan Borgohain, Arup Chanda, Rajdeep Das, Mandakini Gogoi, Karuna Gogoi, Kongkona Joshi, Pyare Laal Kaur, Harpreet Borkakoti, Biswajyoti Bhattacharya, Dibya Ranjan Khan, Abdul Mamood Sen, Satyajit Narain, Kanwar |
| Copyright Year | 2022 |
| Description | The aetiology of non-malaria vector-borne diseases in malaria-endemic, forested, rural, and tribal-dominated areas of Dhalai, Tripura, in north-east India, was studied for the first time in the samples collected from malaria Rapid Diagnostic Kit negative febrile patients by door-to-door visits in the villages and primary health centres. Two hundred and sixty serum samples were tested for the Dengue NS1 antigen and the IgM antibodies of Dengue, Chikungunya, Scrub Typhus (ST), and Japanese Encephalitis (JE) during April 2019–March 2020. Fifteen Dengue, six JE, twelve Chikungunya, nine ST and three Leptospirosis, and mixed infections of three JE + Chikungunya, four Dengue + Chikungunya, three Dengue + JE + Chikungunya, one Dengue + Chikungunya + ST, and one Dengue + ST were found positive by IgM ELISA tests, and four for the Dengue NS1 antigen, all without any travel history. True prevalence values estimated for infections detected by Dengue IgM were 0.134 (95% CI: 0.08–0.2), Chikungunya were 0.084 (95% CI: 0.05–0.13), Scrub were 0.043 (95% CI: 0.01–0.09), and Japanese Encephalitis were 0.045 (95% CI: 0.02–0.09). Dengue and Chikungunya were associated significantly more with a younger age. There was a lack of a defined set of symptoms for any of the Dengue, Chikungunya, JE or ST infections, as indicated by the k-modes cluster analysis. Interestingly, most of these symptoms have an overlapping set with malaria; thereby, it becomes imperative that malaria and these non-malaria vector-borne disease diagnoses are made in a coordinated manner. Findings from this study call for advances in routine diagnostic procedures and the development of a protocol that can accommodate, currently, in practicing the rapid diagnosis of malaria and other vector-borne diseases, which is doable even in the resource-poor settings of rural hospitals and during community fever surveillance. |
| Starting Page | 362 |
| e-ISSN | 20754418 |
| DOI | 10.3390/diagnostics12020362 |
| Journal | Diagnostics |
| Issue Number | 2 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-02-01 |
| Access Restriction | Open |
| Subject Keyword | Diagnostics Tropical Medicine Acute Febrile Illness Infectious Diseases Malaria Non-malaria Vector-borne Diseases Dengue Chikungunya Japanese Encephalitis Scrub Typhus Leptospirosis Malaria-endemic Region Community Fever Surveillance |
| Content Type | Text |
| Resource Type | Article |
