NDLI: The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial

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The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial

Content Provider	MDPI
Author	Thapa, Ngeemasara Park, Hye Jin Yang, Ja-Gyeong Son, Hae Un Jang, Minwoo Lee, Jihyeon Kang, Seung Wan Park, Kyung Won Park, Hyuntae
Copyright Year	2020
Description	This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults. In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the Mini-Mental State Examination (MMSE) and frontal cognitive function: trail making test (TMT) A & B, and symbol digit substitute test (SDST). Resting state electroencephalogram (EEG) was measured in eyes open and eyes closed conditions for 5 minutes each, with a 19-channel wireless EEG device. The VR intervention program (3 times/week, 100 min each session) comprised four types of VR game-based content to improve the attention, memory and processing speed. Analysis of the subjects for group–time interactions revealed that the intervention group exhibited a significantly improved executive function and brain function at the resting state. Additionally, gait speed and mobility were also significantly improved between and after the follow-up. The VR-based training program improved cognitive and physical function in patients with MCI relative to controls. Encouraging patients to perform VR and game-based training may be beneficial to prevent cognitive decline.
Starting Page	1283
e-ISSN	20770383
DOI	10.3390/jcm9051283
Journal	Journal of clinical medicine
Issue Number	5
Volume Number	9
Language	English
Publisher	MDPI
Publisher Date	2020-04-29
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Medical Informatics Virtual Reality Dementia Mild Cognitive Impairment Electroencephalogram
Content Type	Text
Resource Type	Article

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