Loading...
Please wait, while we are loading the content...
Similar Documents
Nanodelivery Strategies for Skin Diseases with Barrier Impairment: Focusing on Ceramides and Glucocorticoids
| Content Provider | MDPI |
|---|---|
| Author | Almeida, Cíntia Filipe, Patrícia Rosado, Catarina Pereira-Leite, Catarina |
| Copyright Year | 2022 |
| Description | The human epidermis has a characteristic lipidic composition in the stratum corneum, where ceramides play a crucial role in the skin barrier homeostasis and in water-holding capacity. Several skin diseases, such as atopic dermatitis and psoriasis, exhibit a dysfunction in the lipid barrier with altered ceramide levels and increased loss of transepidermal water. Glucocorticoids are normally employed in the therapeutical management of these pathologies. However, they have shown a poor safety profile and reduced treatment efficiency. The main objective of this review is to, within the framework of the limitations of the currently available therapeutical approaches, establish the relevance of nanocarriers as a safe and efficient delivery strategy for glucocorticoids and ceramides in the topical treatment of skin disorders with barrier impairment. |
| Starting Page | 275 |
| e-ISSN | 20794991 |
| DOI | 10.3390/nano12020275 |
| Journal | Nanomaterials |
| Issue Number | 2 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-15 |
| Access Restriction | Open |
| Subject Keyword | Nanomaterials Dermatology Stratum Corneum Skin Disorders Ceramides Glucocorticoids Nanoparticles Atopic Dermatitis Psoriasis Xerosis Ichthyosis |
| Content Type | Text |
| Resource Type | Article |
