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Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development
| Content Provider | MDPI |
|---|---|
| Author | Nakmode, Deepa Bhavana, Valamla Thakor, Pradip Madan, Jitender Singh, Pankaj Kumar Singh, Shashi Bala Rosenholm, Jessica M. Bansal, Kuldeep K. Mehra, Neelesh Kumar |
| Copyright Year | 2022 |
| Description | Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre-dissolution of drugs in lipids, surfactants, or mixtures of lipid excipients and surfactants eliminate the dissolution/dissolving step, which is likely to be the rate-limiting factor for oral absorption of poorly water-soluble drugs. In this review, we exhaustively summarize the lipids excipients in relation to their classification, absorption mechanisms, and lipid-based product development. Methodologies utilized for the preparation of solid and semi-solid lipid formulations, applications, phase behaviour, and regulatory perspective of lipid excipients are discussed. |
| Starting Page | 831 |
| e-ISSN | 19994923 |
| DOI | 10.3390/pharmaceutics14040831 |
| Journal | Pharmaceutics |
| Issue Number | 4 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-04-11 |
| Access Restriction | Open |
| Subject Keyword | Pharmaceutics Anesthesiology Lipid Excipients Bioavailability Poorly Soluble Drugs Lipid-based Nanosystems Oral Absorption Computational Modeling |
| Content Type | Text |
| Resource Type | Article |
