NDLI: Friction in Myocardial Anoxia Leads to Negative Excess Entropy Production, Self-Organization, and Dissipative Structures

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Friction in Myocardial Anoxia Leads to Negative Excess Entropy Production, Self-Organization, and Dissipative Structures

Content Provider	MDPI
Author	Jean-Louis, Hébert Alexandre, Vallée Lecarpentier, Yves Claes, Victor Krokidis, Xénophon Schussler, Olivier
Copyright Year	2022
Abstract	Contraction of the heart is caused by actin filaments sliding along myosin filaments. This generates a frictional force inducing wear of the contractile apparatus. We postulated that this process could be exacerbated when the heart was submitted to severe anoxia. Anoxia induced dramatic abnormalities in the molecular properties of actin-myosin crossbridges. We applied the formalism of far-from-equilibrium thermodynamics to the left ventricular papillary muscles (LVPMs) of mammalian rat hearts which had been subjected to a prolonged anoxia (3 h). We showed that when subjected to prolonged anoxia, the heart operated far-from-equilibrium as evidenced by the non-linearity between thermodynamic force (F/T: Frictional force/Kelvin temperature) and thermodynamic flow (v0: myofilament sliding velocity). The rate of entropy production (EPR) was the product of (F/T) and v0. The excess entropy production (EEP) was equal to $\frac{\partial δ^{2} S}{\partial t}$ = $\frac{\partial F}{T} δ$ vo; (S: entropy). The tribological system remained stable when EEP was positive and became unstable when EEP became negative, thus characterizing instability of the system and reflecting the occurrence of self-organization and possibly dissipative structures. After 3 h anoxia, re-oxygenation induced significant reversibility. About 20% of the myosin heads did not recover despite re-oxygenation. These results may be of importance in the context of heart transplantation where the delay between the time of sampling from the donor and the time of the graft installation in the recipient should be as short as possible.
Starting Page	6967
e-ISSN	14220067
DOI	10.3390/ijms23136967
Journal	International Journal of Molecular Sciences
Issue Number	13
Volume Number	23
Language	English
Publisher	MDPI
Publisher Date	2022-06-23
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Biophysics Friction Myocardium Anoxia Far-from-equilibrium Thermodynamics Excess Entropy Production Self-organisation Dissipative Structures
Content Type	Text
Resource Type	Article

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