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The Evolving View of Uremic Toxicity
| Content Provider | MDPI |
|---|---|
| Author | Meijers, Bjorn Lowenstein, Jerome |
| Copyright Year | 2022 |
| Description | Indoxyl sulfate, closely related to indigo, a dye valued for it binding to cloth, has been recognized as a protein-bound solute bound to albumin, present in increased concentration in the serum of patients with impaired glomerular filtration (13). The early studies of Niwa identified indoxyl sulfate as a toxin capable of accelerating the rate of renal damage in subtotal nephrectomized rats (18). Over the past decade other protein-bound solutes have been identified in the plasma of patients with impaired glomerular filtration. Although the early studies, focused on the kidney, identified indoxyl sulfate as a toxic waste product dependent on the kidney for its removal, subsequent observations have identified organic anion transporters on many non-renal tissue, leading to the view that indoxyl sulfate is part of a systemic signaling system. |
| Starting Page | 274 |
| e-ISSN | 20726651 |
| DOI | 10.3390/toxins14040274 |
| Journal | Toxins |
| Issue Number | 4 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-04-12 |
| Access Restriction | Open |
| Subject Keyword | Toxins Urology and Nephrology Protein-bound Solute Uremia Organic Anion Transporter |
| Content Type | Text |
| Resource Type | Article |
