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Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly
| Content Provider | MDPI |
|---|---|
| Author | Ana, Terças-Trettel Lav, ínia Schüler-Faccini Gomes, Julia Sgarioni, Eduarda Boquett, Juliano Silva, Juliana da Ribeiro, Bethânia Galera, Marcial de Oliveira, Thalita de Andrade, Maria Carvalho Carvalho, Isabella Vianna, Fernanda |
| Copyright Year | 2021 |
| Description | Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in utero exposed to ZIKV infection, but born without congenital anomalies, were evaluated. Children with CZS were predominantly infected by ZIKV in the first trimester (p < 0.001) and had mothers with lower educational level (p < 0.001) and family income (p < 0.001). We found higher risk of CZS due the allele rs2297518[A] of NOS2 (OR = 2.28, CI 95% 1.17–4.50, p = 0.015). T allele and TT/CT genotypes of the TNF rs1799724 and haplotypes associated with higher expression of TNF were more prevalent in children with CZS and severe microcephaly (p = 0.029, p = 0.041 and p = 0.030, respectively). Our findings showed higher risk of CZS due ZIKV infection in the first trimester and suggested that polymorphisms in NOS2 and TNF genes affect the risk of CZS and severe microcephaly. |
| Starting Page | 325 |
| e-ISSN | 19994915 |
| DOI | 10.3390/v13020325 |
| Journal | Viruses |
| Issue Number | 2 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-02-20 |
| Access Restriction | Open |
| Subject Keyword | Viruses Infectious Diseases Maternal Exposure Zika Virus Zika Virus Infection Teratogens Congenital Abnormalities Genetic Variation Genetic Polymorphism Disease Susceptibility Inflammation |
| Content Type | Text |
| Resource Type | Article |
