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The Effects of One Anastomosis Gastric Bypass Surgery on the Gastrointestinal Tract
| Content Provider | MDPI |
|---|---|
| Author | Kaniel, Osnat Sherf-Dagan, Shiri Szold, Amir Langer, Peter Khalfin, Boris Kessler, Yafit Raziel, Asnat Sakran, Nasser Motro, Yair Goitein, David Moran-Gilad, Jacob |
| Copyright Year | 2022 |
| Description | One anastomosis gastric bypass (OAGB) is an emerging bariatric procedure, yet data on its effect on the gastrointestinal tract are lacking. This study sought to evaluate the incidence of small-intestinal bacterial overgrowth (SIBO) following OAGB; explore its effect on nutritional, gastrointestinal, and weight outcomes; and assess post-OABG occurrence of pancreatic exocrine insufficiency (PEI) and altered gut microbiota composition. A prospective pilot cohort study of patients who underwent primary-OAGB surgery is here reported. The pre-surgical and 6-months-post-surgery measurements included anthropometrics, glucose breath-tests, biochemical tests, gastrointestinal symptoms, quality-of-life, dietary intake, and fecal sample collection. Thirty-two patients (50% females, 44.5 ± 12.3 years) participated in this study, and 29 attended the 6-month follow-up visit. The mean excess weight loss at 6 months post-OAGB was 67.8 ± 21.2%. The glucose breath-test was negative in all pre-surgery and positive in 37.0% at 6 months (p = 0.004). Positive glucose breath-test was associated with lower reported dietary intake and folate levels and higher vitamin A deficiency rates (p ≤ 0.036). Fecal elastase-1 test (FE1) was negative for all pre-surgery and positive in 26.1% at 6 months (p = 0.500). Both alpha and beta diversity decreased at 6 months post-surgery compared to pre-surgery (p ≤ 0.026). Relatively high incidences of SIBO and PEI were observed at 6 months post-OAGB, which may explain some gastrointestinal symptoms and nutritional deficiencies. |
| Starting Page | 304 |
| e-ISSN | 20726643 |
| DOI | 10.3390/nu14020304 |
| Journal | Nutrients |
| Issue Number | 2 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-12 |
| Access Restriction | Open |
| Subject Keyword | Nutrients Endocrinology and Metabolism Gastric Bypass Small-intestinal Bacterial Overgrowth Pancreatic Exocrine Insufficiency Gut Microbiota |
| Content Type | Text |
| Resource Type | Article |
