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The Role of Triazole and Glucose Moieties in Alkali Metal Cation Complexation by Lower-Rim Tertiary-Amide Calix[4]arene Derivatives
| Content Provider | MDPI |
|---|---|
| Author | Josip, Požar Marija, Cvetnić Matija, Modrušan Vladislav, Tomišić Usenik, Andrea Cindro, Nikola Horvat, Gordan Leko, Katarina |
| Copyright Year | 2022 |
| Description | The binding of alkali metal cations with two tertiary-amide lower-rim calix[4]arenes was studied in methanol, N,N-dimethylformamide, and acetonitrile in order to explore the role of triazole and glucose functionalities in the coordination reactions. The standard thermodynamic complexation parameters were determined microcalorimetrically and spectrophotometrically. On the basis of receptor dissolution enthalpies and the literature data, the enthalpies for transfer of reactants and products between the solvents were calculated. The solvent inclusion within a calixarene hydrophobic basket was explored by means of$ ^{1}$H NMR spectroscopy. Classical molecular dynamics of the calixarene ligands and their complexes were carried out as well. The affinity of receptors for cations in methanol and N,N-dimethylformamide was quite similar, irrespective of whether they contained glucose subunits or not. This indicated that sugar moieties did not participate or influence the cation binding. All studied reactions were enthalpically controlled. The peak affinity of receptors for sodium cation was noticed in all complexation media. The complex stabilities were the highest in acetonitrile, followed by methanol and N,N-dimethylformamide. The solubilities of receptors were greatly affected by the presence of sugar subunits. The medium effect on the affinities of calixarene derivatives towards cations was thoroughly discussed regarding the structural properties and solvation abilities of the investigated solvents. |
| Starting Page | 470 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules27020470 |
| Journal | Molecules |
| Issue Number | 2 |
| Volume Number | 27 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-12 |
| Access Restriction | Open |
| Subject Keyword | Molecules Atomic, Molecular and Chemical Physics Calix[4]arenes Alkali Metal Cations Complexation Solvation Calorimetry Molecular Dynamics |
| Content Type | Text |
| Resource Type | Article |
