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Osteoblast-like Cell Proliferation, ALP Activity and Photocatalytic Activity on Sintered Anatase and Rutile Titanium Dioxide
| Content Provider | MDPI |
|---|---|
| Author | Yokoi, Yukiko |
| Copyright Year | 2021 |
| Description | This study aimed to create a biomaterial from titanium dioxide $(TiO_{2}$), which has been known to have photocatalytic and bone formation promoting effects. I expected that anatase titanium dioxide-based implants could promote bone augmentation and induce bone formation. Powdery anatase $TiO_{2}$ was compression molded and sintered at 700, 800, 900, and 1000 °C to prepare sintered compact samples. X-ray diffraction and scanning electron microscopy were used to observe the surface of these samples. Furthermore, mouse osteoblast-like cells (MC3T3-E1 cell line) were seeded on the samples sintered at different temperatures, and cell proliferation was observed to evaluate the cell proliferation of the samples. The sample sintered at 700 °C was composed of anatase $TiO_{2}$. The samples sintered at 800 °C and 900 °C were confirmed to consist of a mixture of anatase and rutile $TiO_{2}$ crystalline phases. Moreover, the sample sintered at 700 and 800 °C, which contained anatase $TiO_{2}$, showed remarkable photocatalytic activity. Those samples sintered at 1000 °C were transformed to the rutile $TiO_{2}$. The cell proliferation after 7–14-days culturing revealed that cells cultured on the 700 °C sample decreased in number immediately after initiation of culturing. The cells cultured on $TiO_{2}$ sintered at 900 °C markedly proliferated over time with an increase in the alkaline phosphatase activity, showing good MC3T3-E1 cell compatibility of the samples. The sample sintered at 1000 °C, which is rutile $TiO_{2}$, showed the highest increase. |
| Starting Page | 4414 |
| e-ISSN | 19961944 |
| DOI | 10.3390/ma14164414 |
| Journal | Materials |
| Issue Number | 16 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-08-06 |
| Access Restriction | Open |
| Subject Keyword | Materials Cell Tissue Engineering Titanium Dioxide (tio2) Anatase Sintered Cell Proliferation Alkaline Phosphatase (alp) |
| Content Type | Text |
| Resource Type | Article |
