NDLI: SRPassing Co-translational Targeting: The Role of the Signal Recognition Particle in Protein Targeting and mRNA Protection

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SRPassing Co-translational Targeting: The Role of the Signal Recognition Particle in Protein Targeting and mRNA Protection

Content Provider	MDPI
Author	Kellogg, Morgana Miller, Sarah Tikhonova, Elena Karamyshev, Andrey
Copyright Year	2021
Description	Signal recognition particle (SRP) is an RNA and protein complex that exists in all domains of life. It consists of one protein and one noncoding RNA in some bacteria. It is more complex in eukaryotes and consists of six proteins and one noncoding RNA in mammals. In the eukaryotic cytoplasm, SRP co-translationally targets proteins to the endoplasmic reticulum and prevents misfolding and aggregation of the secretory proteins in the cytoplasm. It was demonstrated recently that SRP also possesses an earlier unknown function, the protection of mRNAs of secretory proteins from degradation. In this review, we analyze the progress in studies of SRPs from different organisms, SRP biogenesis, its structure, and function in protein targeting and mRNA protection.
Starting Page	6284
e-ISSN	14220067
DOI	10.3390/ijms22126284
Journal	International Journal of Molecular Sciences
Issue Number	12
Volume Number	22
Language	English
Publisher	MDPI
Publisher Date	2021-06-11
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Cell Biology Ribosome Mrna Translation Signal Recognition Particle (srp) Protein Targeting and Transport Protein Sorting Signal Sequence Protein Quality Control Translational Control
Content Type	Text
Resource Type	Article

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