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Chlorin e6-Biotin Conjugates for Tumor-Targeting Photodynamic Therapy
| Content Provider | MDPI |
|---|---|
| Author | Liu, Wei Ma, Xingqun Jin, Yingying Zhang, Jie Li, Yang Tang, Yuxia Song, Yong Wang, Shouju |
| Copyright Year | 2021 |
| Description | To improve the tumor-targeting efficacy of photodynamic therapy, biotin was conjugated with chlorin e6 to develop a new tumor-targeting photosensitizer, Ce6-biotin. The Ce6-biotin had good water solubility and low aggregation. The singlet-oxygen generation rate of Ce6-biotin was slightly increased compared to Ce6. Flow cytometry and confocal laser scanning microscopy results confirmed Ce6-biotin had higher binding affinity toward biotin-receptor-positive HeLa human cervical carcinoma cells than its precursor, Ce6. Due to the BR-targeting ability of Ce6-biotin, it exhibited stronger cytotoxicity to HeLa cells upon laser irradiation. The IC50 against HeLa cells of Ce6-biotin and Ce6 were 1.28 µM and 2.31 µM, respectively. Furthermore, both Ce6-biotin and Ce6 showed minimal dark toxicity. The selectively enhanced therapeutic efficacy and low dark toxicity suggest that Ce6-biotin is a promising PS for BR-positive-tumor-targeting photodynamic therapy. |
| Starting Page | 7342 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules26237342 |
| Journal | Molecules |
| Issue Number | 23 |
| Volume Number | 26 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-03 |
| Access Restriction | Open |
| Subject Keyword | Molecules Oncology Biotin Photosensitizer Chlorin E6 Photodynamic Therapy |
| Content Type | Text |
| Resource Type | Article |
