NDLI: The Efficacy of Silver-Based Electrospun Antimicrobial Dressing in Accelerating the Regeneration of Partial Thickness Burn Wounds Using a Porcine Model

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The Efficacy of Silver-Based Electrospun Antimicrobial Dressing in Accelerating the Regeneration of Partial Thickness Burn Wounds Using a Porcine Model

Content Provider	MDPI
Author	Do, Thien Bui-Thuan Nguyen, Tien Ngoc-Thuy Ho, Minh Hieu Nguyen, Nghi Thi-Phuong Do, Thai Minh Vo, Dai Tan Hua, Ha Thi-Ngoc Phan, Thang Bach Tran, Phong A. Nguyen, Hoai Thi-Thu Vo, Toi Van Nguyen, Thi-Hiep
Copyright Year	2021
Description	(1) Background: Wounds with damages to the subcutaneous are difficult to regenerate because of the tissue damages and complications such as bacterial infection. (2) Methods: In this study, we created burn wounds on pigs and investigated the efficacy of three biomaterials: polycaprolactone-gelatin-silver membrane (PCLGelAg) and two commercial burn dressings, $Aquacel^{®}$ Ag and $UrgoTul^{TM}$ silver sulfadiazine. In vitro long-term antibacterial property and in vivo wound healing performance were investigated. Agar diffusion assays were employed to evaluate bacterial inhibition at different time intervals. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill assays were used to compare antibacterial strength among samples. Second-degree burn wounds in the pig model were designed to evaluate the efficiency of all dressings in supporting the wound healing process. (3) Results: The results showed that PCLGelAg membrane was the most effective in killing both Gram-positive and Gram-negative bacteria bacteria with the lowest MBC value. All three dressings (PCLGelAg, Aquacel, and UrgoTul) exhibited bactericidal effect during the first 24 h, supported wound healing as well as prevented infection and inflammation. (4) Conclusions: The results suggest that the PCLGelAg membrane is a practical solution for the treatment of severe burn injury and other infection-related skin complications.
Starting Page	3116
e-ISSN	20734360
DOI	10.3390/polym13183116
Journal	Polymers
Issue Number	18
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-09-15
Access Restriction	Open
Subject Keyword	Polymers Wound Dressing Electrospinning Polycaprolactone Gelatin Silver Nanoparticle Antibacterial Property Burn Pig Model
Content Type	Text
Resource Type	Article

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