NDLI: Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa

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Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa

Content Provider	MDPI
Author	Steven, Paul Nisticò Duca, Ester Del Morelli, Paola Bennardo, Luigi Raimondo, Cosimo Di
Copyright Year	2020
Description	Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting areas with a high density of apocrine glands and characterized by subcutaneous nodules that may evolve into fistulas with pus secretion. Methods: The aim of this review is to investigate all current knowledge on cytokine regulation in the pathogenesis of HS. A systematic literature research using the words “cytokine”, “interleukin”, “pathway”, and “hidradenitis suppurativa” was performed in PubMed/Medline and Scopus/Embase databases. A search of the clinicaltrials.gov website for interventional recruiting and completed trials including the term “hidradenitis suppurativa” was also performed up to August 2020. We will discuss the pathogenetic role of various cytokines in HS and potential therapeutic targets for this debilitating disease. Results: The pathophysiology underlying this complex condition has not been clearly defined. An upregulation of various cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-1, IL-17, IL-23, and other molecules seems to be related to this inflammatory condition. Various cells, such as lymphocytes T Helper 1 and 17 and keratinocytes seem to be involved in the genesis of this condition. Conclusions: Several future studies and clinical trials are necessary in order to have new knowledge about HS and to properly treat this complex condition.
Starting Page	8436
e-ISSN	14220067
DOI	10.3390/ijms21228436
Journal	International Journal of Molecular Sciences
Issue Number	22
Volume Number	21
Language	English
Publisher	MDPI
Publisher Date	2020-11-10
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Dermatology Hidradenitis Suppurativa Cytokine Interleukin
Content Type	Text
Resource Type	Article

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