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From Small Molecules Toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics
| Content Provider | MDPI |
|---|---|
| Author | Robert, Ziółkowski Górski, Łukasz Jarczewska, Marta Malinowska, Elżbieta |
| Copyright Year | 2021 |
| Description | This paper focuses on the current state of art as well as on future trends in electrochemical aptasensors application in medical diagnostics. The origin of aptamers is presented along with the description of the process known as SELEX. This is followed by the description of the broad spectrum of aptamer-based sensors for the electrochemical detection of various diagnostically relevant analytes, including metal cations, abused drugs, neurotransmitters, cancer, cardiac and coagulation biomarkers, circulating tumor cells, and viruses. We described also possible future perspectives of aptasensors development. This concerns (i) the approaches to lowering the detection limit and improvement of the electrochemical aptasensors selectivity by application of the hybrid aptamer–antibody receptor layers and/or nanomaterials; and (ii) electrochemical aptasensors integration with more advanced microfluidic devices as user-friendly medical instruments for medical diagnostic of the future. |
| Starting Page | 724 |
| e-ISSN | 14248220 |
| DOI | 10.3390/s21030724 |
| Journal | Sensors |
| Issue Number | 3 |
| Volume Number | 21 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-01-21 |
| Access Restriction | Open |
| Subject Keyword | Sensors Analytical Chemistry Aptasensors Electrochemistry Medical Diagnostics Selex Metal Cations Cancer Biomarkers Microbial Toxins |
| Content Type | Text |
| Resource Type | Article |
