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$Na_{2}$S-Mediated One-Pot Selective Deoxygenation of α-Hydroxyl Carbonyl Compounds including Natural Products
| Content Provider | MDPI |
|---|---|
| Author | Xu, Xiaobo Yan, Leyu Zhang, Zhi-Kai Lu, Bingqing Guo, Zhuangwen Chen, Mengyue Cao, Zhong-Yan |
| Copyright Year | 2022 |
| Description | A practical method for the deoxygenation of α-hydroxyl carbonyl compounds under mild reaction conditions is reported here. The use of cheap and easy-to-handle $Na_{2}S·9H_{2}$O as the reductant in the presence of $PPh_{3}$ and N-chlorosuccinimide (NCS) enables the selective dehydroxylation of α-hydroxyl carbonyl compounds, including ketones, esters, amides, imides and nitrile groups. The synthetic utility is demonstrated by the late-stage deoxygenation of bioactive molecule and complex natural products. |
| Starting Page | 4675 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules27154675 |
| Journal | Molecules |
| Issue Number | 15 |
| Volume Number | 27 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-07-22 |
| Access Restriction | Open |
| Subject Keyword | Molecules Deoxygenation Chlorination Dechlorination One-pot |
| Content Type | Text |
| Resource Type | Article |
