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Influence of Ultra-Processed Foods Consumption on Redox Status and Inflammatory Signaling in Young Celiac Patients
| Content Provider | MDPI |
|---|---|
| Author | Rafael, Martín-Masot Nestares, Teresa Flor-Alemany, Marta Bonavita, Antonela Maldonado, José Aparicio, Virginia A. |
| Copyright Year | 2021 |
| Description | The current study was designed to assess the influence of consumption of ultra-processed (UPF) on oxidative/antioxidant balance and evoked inflammatory signaling in young patients with celiac disease (CD). The study included 85 children. The celiac group (n = 53) included children with CD with a long (>18 months, n = 17) or recent (n = 36) adherence to a gluten-free diet (GFD). The control group (n = 32) included healthy children with a significantly higher consumption of UPF compared to the control group, both expressed as kcal/day (p = 0.043) and as percentage of daily energy intake (p = 0.023). Among children with CD, the group with the lowest consumption of UPF (below the 50% of daily energy intake) had a greater Mediterranean diet (MD) adherence and higher moderate physical activity levels. In addition, CD children with the lowest consumption of UPF had healthier redox (lower soluble superoxide dismutase-1 and 15-F2t-isoprostanes) and inflammatory profiles (lower macrophage inflammatory protein-1α) compared to the group with the highest consumption of UPF (all, p < 0.05) regardless of the time on a GFD. These findings highlight the importance of a correct monitoring of the GFD. An unbalanced GFD with high consumption of UPF and an unhealthy pattern with less physical activity and worse adherence to MD results in a worse inflammatory profile, which could act as a parallel pathway that could have important consequences on the pathophysiology of the disease. |
| Starting Page | 156 |
| e-ISSN | 20726643 |
| DOI | 10.3390/nu13010156 |
| Journal | Nutrients |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-01-06 |
| Access Restriction | Open |
| Subject Keyword | Nutrients Nutrition and Dietetics Celiac Disease Ultra-processed Foods Gluten-free Diet Inflammatory Signaling Oxidative Stress Children |
| Content Type | Text |
| Resource Type | Article |
