NDLI: How to Assess Diabetic Kidney Disease Progression? From Albuminuria to GFR

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How to Assess Diabetic Kidney Disease Progression? From Albuminuria to GFR

Content Provider	MDPI
Author	Clara, García-Carro Ana, Sánchez-Fructuoso Vergara, Ander Bermejo, Sheila Azancot, María de la Nieta, M. Sánchez Agraz, Irene Soler, María
Copyright Year	2021
Description	Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes and dramatically increases the cardiovascular risk in these patients. Currently, DKD is severely infra-diagnosed, or its diagnosis is usually made at advanced stages of the disease. During the last decade, new drugs have demonstrated a beneficial effect in terms of cardiovascular and renal protection in type 2 diabetes, supporting the crucial role of an early DKD diagnosis to permit the use of new available therapeutic strategies. Moreover, cardiovascular and renal outcome trials, developed to study these new drugs, are based on diverse cardiovascular and renal simple and composite endpoints, which makes difficult their interpretation and the comparison between them. In this article, DKD diagnosis is reviewed, focusing on albuminuria and the recommendations for glomerular filtration rate measurement. Furthermore, cardiovascular and renal endpoints used in classical and recent cardiovascular outcome trials are assessed in a pragmatic way.
Starting Page	2505
e-ISSN	20770383
DOI	10.3390/jcm10112505
Journal	Journal of clinical medicine
Issue Number	11
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-06-05
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Endocrinology and Metabolism Diabetic Kidney Disease Diabetes Mellitus Chronic Kidney Disease
Content Type	Text
Resource Type	Article

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