Loading...
Please wait, while we are loading the content...
Similar Documents
Synthesis, X-ray Structure, Antimicrobial and Anticancer Activity of a Novel $[Ag(ethyl-3-quinolate)_{2}$(citrate)] Complex
| Content Provider | MDPI |
|---|---|
| Author | Altowyan, Mezna Saleh El-Naggar, Mostafa A. Abu-Youssef, Morsy A. M. Soliman, Saied M. Haukka, Matti Barakat, Assem Badr, Ahmed M. A. |
| Copyright Year | 2022 |
| Abstract | A novel Ag(I) citrate complex with ethyl-3-quinolate (Et3qu) was synthesized. Its structure was confirmed using X-ray single crystal to be [Ag(Et3qu)2(citrate)]. It crystallized in the Triclinic crystal system and P-1 space group with unit cell parameters of a = 8.6475(2) Å, b = 11.4426(3) Å, c = 15.2256(3) Å, α = 73.636(2)°, β = 79.692(2)° and γ = 86.832(2)°, while the unit cell volume was 1422.19(6) Å3. In the unit cell, there are two [Ag(Et3qu)2(citrate)] molecules and one unit as the asymmetric formula. The molecular structure comprised one Ag(I) coordinated with two Et3qu molecules via two almost equidistant Ag-N bonds and one citrate ion acting as a mono-negative monodentate ligand via a short Ag-O bond (2.5401(14) Å). Hence, Ag(I) is tri-coordinated and has a highly distorted triangular planar coordination geometry which is more like to be described as a slightly distorted T-shape. The supramolecular structure of the [Ag(Et3qu)2(citrate)] complex was analyzed using Hirshfeld calculations. The H···H (39.3–40.1%), O···H (33.2-34.0%), C···C (9.1–9.5%) and C···H (7.2–7.4%) contacts shared significantly in the packing of the studied Ag(I) complex. The antimicrobial and anticancer activities of the Ag(I) complex were investigated. The [Ag(Et3qu)2(citrate)] complex has broad-spectrum antimicrobial activity specifically against the fungus A. fumigatus. In addition, the IC50 values of 1.87 ± 0.09 µg/mL and 0.95 ± 0.06 µg/mL against the breast MCF-7 and lung A-549 cell lines, respectively, revealed the potent anticancer activity of the [Ag(Et3qu)2(citrate)] complex compared to the free Et3qu (IC50 = 30.64 ± 1.98 and 22.89 ± 1.48 µg/mL, respectively). |
| Starting Page | 356 |
| e-ISSN | 20734352 |
| DOI | 10.3390/cryst12030356 |
| Journal | Crystals |
| Issue Number | 3 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-03-07 |
| Access Restriction | Open |
| Subject Keyword | Crystals Inorganic Chemistry Hirshfeld X-ray Antimicrobial Anticancer Ag/quinoline/citrate Complex |
| Content Type | Text |
| Resource Type | Article |
